联系方式：zhangmohan1121@163.com

简介：

张默涵，女，硕导，1986年1月出生，2017年毕业于日本奈良先端科技大学院大学，获得理学博士学位。曾在美国加州大学戴维斯分校交流。2018年3月-2021年9月在深圳大学从事博士后和副研究员工作。2021年10月加入广西民族大学化学化工学院化学系。

主要研究方向：

阿尔茨海默症的发病机制研究及抗阿尔茨海默症的活性小分子筛选及先导化合物的合成。

近年来发表的文章：

(1) Mohan Zhang, Hulin Tai, Sachiko Yanagisawa, Masaru Yamanaka, Takashi Ogura, and Shun Hirota*. Resonance Raman Studies on Heme Ligand Stretching Modes in Methionine80-Depleted Cytochrome c: Fe−His, Fe−O2, and O−O Stretching Modes. The Journal of Physical Chemistry B 2023, 127, 2441−2449.

(2) Mohan Zhang^#, Qiuping Wu^#, Ruoxi Zhao, Xuanbao Yao, Xiubo Du, Qiong Liu, Guohua Lv^* and Shifeng Xiao^*, Isobavachalcone ameliorates cognitive deficits, Aβ and tau pathologies in triple-transgenic mice of Alzheimer's disease. Food & Function, 2021, 12: 7749–7761.

(3) Shifeng Xiao, Qiuping Wu, Weicong Zhong, Xuanbao Yao, Junyi Zhao, Qiong Liu, Mohan Zhang* The inhibitory effects of isobavachalcone on tau protein aggregation, tau phosphorylation and oligomeric tau-induced apoptosis. ACS Chemical Neuroscience, 2021, 12：123-132.

(4) Mohan Zhang, Qiuping Wu, Xuanbao Yao, Junyi Zhao, Weicong Zhong, Qiong Liu and Shifeng Xiao*, Xanthohumol inhibits tau protein aggregation and protects cells against tau aggregate. Food & Function, 2019, 10: 7865-7874.

(5) Mohan Zhang, Tsukasa Nakanishi, Masaru Yamanaka, Satoshi Nagao, Sachiko Yanagisawa, Yasuhito Shomura, Naoki Shibata, Takashi Ogura, Yoshiki Higuchi, and Shun Hirota*，Rational design of domain swapping-based c-type cytochrome heterodimers using chimeric proteins，ChemBioChem, 2017, 18：1712-1715.

(6) Yingwu Lin, Satoshi Nagao, Mohan Zhang, Yasuhito Shomura, Yoshiki Higuchi, and Shun Hirota*，Rational design of heterodimeric protein using domain swapping for myoglobin，Angewandte Chemie International Edition, 2015，54：511-515.