联系方式：E-mail:shenliqun1999@163.com

简介：

申利群，男，药物化学博士，教授，博士生导师。主持完成国家自然科学基金，广西高校优秀人才资助计划，广西教育厅重点项目、广西自治区自然科学基金、广西重点研发项和广西科技重大专项项目十多项项；参与科技部等国家级项目3项，主持横向项目5项。先后在Angew. Chem. Int. Ed. Engl，J.Am.Chem.Soc，Molecular Carcinogenesis.，Drug Design, Development and Therapy ，steroids，J Food Process Preserv，Journal of Molecular Liquids等国内外期刊上发表论文80多篇，获专利授权15项。

长期从事药物化学、制药工艺学与药物合成反应教学。

研究方向：

主要从事计算机辅助药物设计合成、药物绿色合成方法学及药物新剂型开发研究。

工作经历：

1. 2010/1 - 至今    广西民族大学，化学化工学院，教授

2. 2014/2 - 2015/2 The Ohio State University，college of pharmacy，访问学者

3. 2004/07-2009/12 河池学院，化学与生命科学系，讲师/副教授

4. 1993/07-2001/08  湖南湘中制药有限公司，助理工程师

主持科研项目及人才计划项目情况：

1. 广西科技重大专项（2022AA12003-04），前沿新材料医用有机硅凝胶及产品研究开发与产业化子课题，2023/01-2025/12, 45 万元，主持.

2. 广西重点研发计划（桂科AB20238008），助焊剂用高稳定性氢化丙烯海松酸关键技术研发及产业化，2020/10/01-2023/09/30，50万，主持.

3. 国家自然科学基金项目，21762006，基于Survivin蛋白靶点的甘草查尔酮B衍生物设计合成及抗肿瘤作用机理研究，2018/01-2021/12，38万元，主持.

4. 广西科技重大专项项目（桂科AA17204090），广西药用植物沉香的产业化研究子项目，2017/09-2020/12，30万元，主持.

近五年公开发表论文情况：

1. Yingqi Qiu, Yuanmeng Wang, Jiahao Lu, Qinghua Zhu, Li Jia, Fuhou Lei, Liqun Shen^*, Lihe Jiang, Aiqun Wu. Synthesis, spectroscopic analysis, DFT, docking, MD and antioxidant activity of tetrahydrocurcumin. Journal of biomolecular structure and dynamics. 2023, 1-13, doi：10.1080/07391102.2023.2275189

2. Yingqi Qiu, Wuji Lai, Yu Feng, Qinghua Zhu, Yuanmeng Wang, Lihe Jiang, Fuhou Lei, Liqun Shen^* and Aiqun Wu .  DFT, FMO, ESP, Molecular Docking and Molecular Dynamics Simulations of Bis-2-(2-Phenethyl)Chromone as a Potential PPAR Agonist .  Letters in Organic Chemistry, 2023, 20, 678-687

3. Jia-Hao Lu, Wu-Ji Lai, Li-He Jiang, Fu-Hou Lei, Li-Qun Shen^*, and Ai-Qun Wu,  Design, Synthesis, and Molecular Docking Study of Novel 3-Cyanopyridine Derivatives for the Anti-Cancer Drug Target Survivin Protein .  Medicinal Chemistry,  2023, 19, 246-262

4. Wu-Ji Lai, Jia-Hao Lu, Rui Jiang, Lei Zeng, Li-Qun Shen^*. The mechanisms and molecular properties about isomerization of resin acids, synthesis of acrylopimaric acid based on DFT Calculation. J Phys Org Chem. 2022; e4393.

5. Wu-Ji Lai, Cheng-piao Tian, Jia-Hao Lu, Hua Zhu, Li-he Jiang, Fu-Hou Lei, Li-Qun Shen*, Ai-Qun Wu. Insights into solvent, spectroscopic and pharmacological properties of rhynchophylline and isorhynchophylline: Experimental, DFT, MD and docking. Journal of Molecular Liquids. 2021, 340,117208.

6. Chengpiao Tian, Aiqun Wu, Caiyun Yao, Zhijun Song, Liqun Shen^* ,Lili He. UHPLC−QTOF−MS based metabolite profiling analysis and thecorrelation with biological properties of wild and artificial agarwood. Journal of Pharmaceutical and Biomedical Analysis, 2021, 194: 113782.

7. Wu-Ji Lai Computation, Jia-Hao Lu, Zhan-Wang Shi, Fu-Hou Lei , Wan-Ling Qi, Jun Yang, Zhou Xing, Ai-Qun Wu*, Li-Qun Shen*. Thermal isomerism and pyrolysis mechanism of α-pinene and β-pinene in a solvent-free solution and ethanol based on density functional theory. Chemical Physics, 2021,544, 111103.

8. Cheng‑piao Tian, Xing‑dong Yao, Jia‑hao Lu, Li‑qun Shen*, Ai‑qun Wu. GC–MS fingerprints of essential oils from agarwood grown in wild and artificial environments. Trees, 2021, 35(6):2105-2117.

9. Wu-Ji Lai, Jia-Hao Lu, Li-He Jiang, Fu-Hou Lei , Li-Qun Shen* , Ai-Qun Wu*, Jun Yang,  Wan-Ling Qi.  Structural stabilities and transformation mechanism of rhynchophylline and isorhynchophylline in aqueous and methanol solution based on high-performance liquid chromatography and density functional theory. Journal of Molecular Structure, 2021, 1236: 130300.

10. 伍燕,杜俊希,张娟，申利群*.华丽牛肝菌菌塘土壤细菌多样性的高通量测序分析.中国食用菌,2021,40（1）:84~90.

11. 伍燕，汪伟，王燕，申利群*,.2种牛肝菌分子鉴定及营养成分分析，现代食品科技，2021,37（09）:102-108.

12. Cheng-piao Tian, Ya-ling Song, Hai-tang Xu, Xing-dong Yao, Si-qi Niu, Li-qun Shen*, Li-li He*. Chemical characterization of ginger and vinegar soaked ginger: Changes in volatiles and chemical profile. Journal of Food Processing & Preservation, 2020 , 44 (5): 1-15.

13. 伍燕, 朱家豪, 汪伟, 申利群*. 暗褐网柄牛肝菌多糖 AHP 分离纯化和结构研究. 食品与发酵工业, 2020, 46(8): 92-96.

14. 伍燕,何元琴,易君明,申利群*.不同大蒜精油成分及生物活性对比分析.现代食品科技,2020, 6, 75-81.

15. 伍燕,徐峰,李小双,朱家豪,申利群*. 皱盖疣柄牛肝菌多糖 LRP- I 和 LRP- II 结构表征及抗氧化活性分析.食品工业科技，2020,05,18.

16. 周菊英,邹梦君,廖华珍,赵彦芝,许海棠,申利群*.无溶剂法制备丙烯海松酸蔗糖酯及其在空气-水界面吸附行为研究.林产化学与工业,2020,2:69-75.

17. Lingyuan Xu, Sensen Qiu, Lehe Yang, Haitang Xu, Xu Liu, Shiqian Fan, Ri Cui, Weitao Fu, Chengguang Zhao, Liqun Shen^*, Liangxing Wang^*, Xiaoying Huang^*. Aminocyanopyridines as anti-lung cancer agents by inhibiting the STAT3 pathway Molecular Carcinogenesis. 2019; 58:1512–1525.

18. Lingyuan Xu, Lingxi Shi, Sensen Qiu,  Siyu Chen, Mengsha Lin, Youqun Xiang, Chengguang Zhao, Jiandong Zhu, Liqun Shen^*, Zhigui Zuo ^* . Design, Synthesis, And Evaluation Of Cyanopyridines As Anti-Colorectal Cancer Agents Via Inhibiting STAT3 Pathway. Drug Design, Development and Therapy, 2019:13 3369–3381.

19. 田程飘，朱伟伟，宋雅玲，牛思琪，申利群*，吴爱群*.生姜和醋泡生姜抗菌、抗氧化和抗肿瘤活性比较研究.食品工业科技,2019,14:18-23.

20. 田程飘，宋雅玲，许海棠，牛思琪，吴志鸿，申利群*.超临界和水蒸汽蒸馏提取沉香精油成分分析及抗氧化、抑菌活性对比研究．中国中药杂志,2019,44(18):4000-4008.

21. Ya-Ling Song, Cheng-Piao Tian, Yan Wu, Li-he Jiang, Li-Qun Shen*. Design, synthesis and antitumor activity of steroidal pyridine derivatives based on molecular docking. Steroids, 2019, 143,53–61.

获得学术奖励：

1. 申利群（7/15），广西壮族自治区科技进步二等奖，2019.

2. 申利群（9/10），教育部自然科学一等奖，2017.

3. 申利群(2/4)，湖南省科技进步奖三等奖，2012.

4. 申利群(2/4)，湖南省邵阳市科技进步一等奖，2011.