联系方式：zjy_03@126.com

个人简介：

张金彦，博士，教授，化学工程与技术硕士生导师、材料与化工专业硕士生导师。主要从事药物多晶型、药物共晶及药物纯化等方面研究。近年主持完成国家自然科学基金1项，广西自然科学基金3项。主持完成广西区教改项目1项；作为主要完成人参加了多项国家自然科学基金、省部级项目。申请国家发明专利3项，授权1项；在高水平期刊发表论文 项。主要承担《分离工程》、《化工热力学》及《制药工程与工艺设计》等课程。

研究领域：

主要从事药物多晶型、药物共晶及药物纯化等方面研究

近五年作为负责人主持科研项目情况：

(1)L-苯丙氨酸多晶型成核及晶型转化研究，广西自然基金青年基金项目（2014GXNSFBA118037），2014/06-2017/06，5万元.

(2)基于水活度的药物热力学及转晶过程研究，国家自然基金青年基金项目（21606056）,2017/01-2020/12,20万；

(3) 多糖-拉莫三嗪共晶分子设计及原位热动力学分析，广西自然基金面上项目， (2017GXNSFAA198091)，2017.09.30-2020.09.29，12万元；

(4)以ClassⅡ型吡嗪酰胺或Ⅳ型非那吡啶药物为模板的共晶分子设计及以性能为导向的过程调控研究，广西自然基金面上项目（2020GXNSFAA159112），2020.07.01-2023.07.01,10万元

近五年公开发表论文情况：

(1)Zhihang Liang, Xiaohan Li, Shaochang Ji, Jiayi Cheng, Haiquan Jing, Jinyan Zhang,*and Yanyue Lu. Pyrazinamide-3-Nitrophthalic Acid Cocrystals:Synthesis, Transformation,and Property Evaluation, Crystal Growth & Design, 2023, 23, 11: 8646-8655

(2)Jinyan Zhang, Zhihan Liang, Fei Yang,Shaochang Ji, Ping Lan and Yexin Liao(*).Unique sandwich structure of pyrazinamide-methylmalonic acid cocrystal: ternary phase diagrams, characterization and property evaluation.CrystEngComm, 2022,24,2650-2659

(3)Jinyan Zhang, Xiaohan Li, Shaochang Ji, LüYan Zhuo, Ping Lan, Lin Hao and Yexin Liao (*). Solid-liquid phase equilibrium of mycophenolic acid in 14 mono-solvents: Measurements, correlation, solvent effect and molecular simulation. Journal of Molecular Liquids,2022,366(11):120240

(4)Jinyan Zhang(*),Zhihan Liang,Shaochang Ji,Xiaofang Wang,Ping Lan.The thermal behavior of pyrazinamide in 12 solvents from 288.15 to 328.15k.Journal of Molecular Liquids,2021,329:115572

(5)Wenjie Kuang,Shaochang Ji,Shenmin Xu,Ping Lan,Anping Liao,Juying Zhou,Jinyan Zhang(*).Thermodynamic and Crystallization of Lamotrigine Cocrystal. Crystal Growth & Design, 2019, 19, 11: 6603-6610

(6)Wenjie Kuang, Shaochang Ji, Yufeng Wei , Jinyan Zhang(*) and Ping Lan . A New 1:1 Cocrystal of Lamotrigine and 1,2,3,6-4hydrophthalimide: Discovery, Characterization, and Construction of Ternary Phase Diagrams. CrystEngComm, 2020, 22:2681-2688

(7)Wenjie Kuang, Shaochang Ji, Xiaofang Wang, Jinyan Zhang(*); Ping Lan(*). Relationship between crystal structures and physicochemical properties of lamotrigine cocrystal. Powder Technology,2021,380:18-25

(8)Wenjie Kuang,Shaochang Ji,Xiaofang Wang,Anping Liao,Ping Lan,Jinyan Zh ang(*). Solid–Liquid Equilibrium of Lamotrigine in 12 Pure Solvents from T = 2 83.15 to 323.15 K: Experimental Determination and Thermodynamic Modeling. Journal of Chemical Engineering & Data, 2020, 65, 1:169-176

(9)Jinyan Zhang, Xiaoxue Cao, Shaochang Ji, Ping Lan , Anping Liao(*) . Solu bility and transformation behavior of l-phenylalanine anhydrate with amino acid additives [J]. Journal of Thermal Analysis and Calorimetry, 2018, 131:1777–17 81

(10)Xiaoxue Cao, Shaochang Ji,Wenjie Kuang, Anping Liao,Ping Lan, Jinyan Z hang(*).Ternary phase diagrams and metastable zone width of azithromycin in water-acetone solvent mixtures. Journal of Thermal Analysis and Calorimetry, 2020, 140:1 207189051087 31/38 897-1905

(11)Xiaoxue Cao, Shaochang Ji ,Wenjie Kuang,Anping Liao ,Ping Lan, Jinyan Zhang(*). Solubility determination and correlation for azithromycin monohydrate and dihydrate in solvent mixtures. Journal of Molecular Liquids, 2020, 301:1 12398-112406

(12)Xiaoxue Cao, Shaochang Ji, Yumei Ben, Wenjie Kuang, Anping Liao,Ping Lan , Jinyan Zhang(*). The Methods to Crystallize Anhydrous L-Phenylalanine from Methanol-Water Solution. Crystals, 2020, 10: 60-74