联系方式： E-mail: kongfandong501@126.com
简介：
孔凡栋，男，山东菏泽人，中国海洋大学药物化学专业医学博士，化学化工学院药学系主任，国家基金通讯评审专家，广西科技项目通讯和会议评审专家，中国菌物学会菌物化学专业委员会委员，Marine drugs期刊客座编辑。主要从事真菌活性代谢产物研究。开展海洋真菌次级代谢产物进行系统研究，获得代谢产物300余个，其中新化合物100余个，包括全新骨架的化合物7个。部分化合物显示有很强的抑菌、细胞毒、细菌群体感应系统抑制、抗病毒和磷酸蛋白酪氨酸激酶抑制活性。目前共参与发表SCI论文80余篇，其中第一作者或通讯作者SCI论文20余篇，包括6篇天然产物化学顶级期刊（5篇Journal of natural products和1篇Organic letters）。主持和完成国家自然科学基金和省部级基金等共12项，申请和授权发明专利5项。
研究领域：
研究领域为天然药物化学，主要从事微生物和民族药物中先导化合物的筛选和发现研究。
作为负责人主持科研项目情况：
1. 国家自然科学基金地区项目（2024-2027）：基于TMAO拟生境培养策略的深海真菌中新型谷胱甘肽还原酶抑制剂研究（32万，主持，在研）
2. 广西民族大学A类相思湖创新团队（2021-2024）（60万，主持，在研）
3. 广西科技基地和人才专项（2022-2024）, 三株海洋真菌中新型抗菌增效剂研究 （20万，主持，在研）
4. 广西自然科学基金青年科学基金项目（2022-2024）, 三株海洋动物源真菌中新型PTP1B抑制剂研究 （8万，主持，在研）
5. 广西民族大学校级自然科学基金（2021-2024）（6万，主持，在研）
6. 广西民族大学引进人才科研启动费（2022-2025）（40万，主持，在研）
7. 国家自然科学基金青年项目（2017-2019）：三株海洋动物内生真菌中革兰氏阴性菌群体感应抑制剂研究（24万，主持，已结题）
8. 海南省自然科学基金面上项目（2017-2018）：两株文蛤内生真菌中革兰氏阴性菌群体感应抑制剂研究（8万，主持，已结题）
9. 海南省自然科学基金青年项目（2020-2022）：海口湾方格星虫来源真菌中具有杀根结线虫作用的次生代谢产物研究（5万，主持，已结题）
10. 中国热带农业科学院青年科技骨干人才项目（2020-2023）（40万，主持，已结题）
11. 中国热带农业科学院国家自然科学基金培育项目（2020）（10万，主持，已结题）
12. 农业部中央公益性基本科研业务费（2016-2020）：天然降血糖活性分子研究（160万，主持，已结题）
公开发表论文情况：
(1) Ren-Shuai Zhang; Na Xiao; Qi Xu; Qiu-Yu Gong; Fan-Dong Kong (corresponding author); Hongfei Jiang. Pleiotropic effects of a mitochondrion-targeted glutathione reductase inhibitor on restraining tumor cells, European Journal of Medicinal Chemistry, 2023, 248: 115069.
(2) Fei Zhang; Li Yang; Qing-Yi Xie; Jiao-Cen Guo; Qing-Yun Ma; Lu-Ting Dai; Li-Man Zhou; Hao-Fu Dai. Fan-Dong Kong (corresponding author); Du-Qiang Luo; You-Xing Zhao; Diverse indole-diterpenoids with protein tyrosine phosphatase 1B inhibitory activities from the marine coral-derived fungus Aspergillus sp. ZF-104, Phytochemistry, 2023, 216: 113888.
(3) Cong Wang; Yu-Fei Wang; Jian Sun; Shi-Yi Wang; Wei-Sheng Du; Li-Man Zhou; Fan-Dong Kong (corresponding author). A Pair of New Spirocyclic Alkaloid Enantiomers with TrxR Inhibitory Activities Were Isolated from Marine-Derived Aspergillus ruber TX-M4-1, Journal of Ocean University of China, 2023, 22:1677-1682.
(4) Ren-Shuai Zhang; Jia-Ke Gao; Gao-Xiang Zhao; Li-Man Zhou; Fan-Dong Kong (corresponding author); Tao Jiang; Hong-Fei Jiang. Tetrazine bioorthogonal chemistry makes nanotechnology a powerful toolbox for biological applications, Nanoscale, 2023, 15: 461.
(5) Zimin Wang; Mallique Qader; Yu-Fei Wang; Fan-Dong Kong(corresponding author); Qi Wang; Cong Wang ; Progress in the discovery of new bioactive substances from deep-sea associated fungi during 2020-2022, Frontiers in Marine Science, 2023, 2023: 1232891.
(6) Ming-Yang Chen; Fan-Dong Kong (co-first); Li Yang; Qing-Yun Ma; Qing-Yi Xie; Jing Yu; Peng-Wei Chen; Li-Man Zhou,; You-Gen Wu; Hao-Fu Dai; You-Xing Zhao. Phenethoxy Derivatives with Anti-inflammatory Activities from the Betelnut Endophytic Trichoderma asperellumG10, Journal of Natural Products , 2022, 85: 1193-1200.
(7) Guo-Jun Pan; Yan-Ling Li; XinYu Che; Dan Tian; Wen-Jie Han; Zi-Min Wang;Yan-Fen Zhao; Shuang Ren; Yi-Ru Xu; Gang-Ping Hao; Meng-Fei Guo; Na Xiao*; Fan-dong Kong*; New Thio-Compounds and Monoterpenes with anti-Inflammatory Activities from the Fungus Aspergillus sp. CYH26, Frontiers in Microbiology, 2021, 12:668938. (IF = 4.235, 中科院二区)
(8) Fan-Dong Kong; Tian-Feng Yi; Qing-Yun Ma; Qing-Yi Xie; Li-Man Zhou; Jing-Ping Chen; Hao-Fu Dai; You-Gen Wu; You-Xing Zhao. Biphenyl metabolites from the patchouli endophytic fungus Alternaria sp. PfuH1. Fitoterapia, 2020.104708. (IF = 2.527, 中科院三区)
(9) Jiao-Chen Guo; Fan-Dong Kong (co-first); Qing-Yun Ma; Qing-Yi Xie; Ren-Shuai Zhang; Hao-Fu Dai; You-Gen Wu; You-Xing Zhao. Meroterpenoids With Protein Tyrosine Phosphatase 1B Inhibitory Activities From the Fruiting Bodies of Ganoderma ahmadii, Frontiers in chemistry, 2020.00279.
(10) Fan-Dong Kong; Peng Fan; Li-Man Zhou; Qing-Yun Ma; Qing-Yi Xie; Hai-Zhou Zheng; Zhi-Hui Zheng; Ren-Shuai Zhang; Jing-Zhe Yuan; Hao-Fu Dai; Du-Qiang Luo; You-Xing Zhao. Penerpenes A–D, Four Indole Terpenoids with Potent Protein Tyrosine Phosphatase Inhibitory Activity from the Marine-Derived Fungus Penicillium sp. KFD28. Organic letters, 2019, 21: 4864-4867.
(11) Fan-Dong Kong; Shengliang Zhang; Shuang-Qing Zhou; Qing-Yun Ma; Qing-Yi Xie; Jin-Ping Chen; Jing-Zhe Yuan; Hao-Fu Dai; Xiaolong Huang; You-Xing Zhao. Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus Aspergillus sp. HNMF114. Journal of Natural Products, 2019, 82, 3456-3463.
(12) Li-Man Zhou; Fan-Dong Kong (co-first); Peng Fan; Qing-Yun Ma; Qing-Yi Xie; Hai-Zhou Zheng; Zhi-Hui Zheng; Jing-Zhe Yuan; Hao-Fu Dai; Du-Qiang Luo; You-Xing Zhao. Indole-Diterpenoids with Protein Tyrosine Phosphatase Inhibitory Activities from the Marine-Derived Fungus Penicillium sp. KFD28, Journal of Natural Products, 2019, 82: 2638-2644.
(13) Li-Man Zhou; Fan-Dong Kong (co-first); Qing-Yi Xie; Qing-Yun Ma; Zhong Hu; Du-Qiang Luo; You-Xing Zhao. Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18. Marine drugs, 2019, 17: 219.
(14) Fan-Dong Kong; Xiao-Long Huang; Qing-Yun Ma; Qing-Yi Xie; Pei Wang; Peng-Wei Chen; Li-Man Zhou; Jing-Zhe Yuan; Hao-Fu Dai; Du-Qiang Luo; You-Xing Zhao, Helvolic acid derivatives with antibacterial activities against Streptococcus agalactiae from the marine-derived fungus Aspergillus fumigatus HNMF0047. Journal of Natural Products, 2018, 81: 1869-1876.
(15) Guo-Liang Zhu; Fan-Dong Kong (co-first); Yi Wang; Peng Fu; Wei-Ming Zhu. Cladodionen, a cytotoxic hybrid polyketide from the marine-derived Cladosporium sp. OUCMDZ-1635. Marine drugs, 2018, 16: 71-78.
(16) Chang-Liang An; Fan-Dong Kong (co-first); Qing-Yun Ma; Qing-Yi Xie; Jing-Zhe Yuan; Li-Man Zhou; Hao-Fu Dai; Zhi-Fang Yu; You-Xing Zhao, Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66. Marine drugs, 2018, 16: 468-478.
(17) Fan-Dong Kong; Qing-Yun Ma; Sheng-Zhuo Huang; Pei Wang; Jun-Feng Wang; Li-Man Zhou; Jing-Zhe Yuan; Hao-Fu Dai; You-Xing Zhao, Chrodrimanins K–N and related meroterpenoids from the fungus Penicillium sp. SCS-KFD09 isolated from a marine worm, Sipunculus nudus, Journal of Natural Products, 2017, 80: 1039-1047.
(18) Fan-Dong Kong; Li-Man Zhou; Qing-Yun Ma; Sheng-Zhuo Huang; Pei Wang; Hao-Fu Dai; You-Xing Zhao, Metabolites with Gram-negative bacteria quorum sensing inhibitory activity from the marine animal endogenic fungus Penicillium sp. SCS-KFD08, Archives of Pharmacal Research, 2017, 40: 25-31.
(19) Fan-Dong Kong; Qing-Yun Ma; Sheng-Zhuo Huang; Shuang Yang; Lin-Ran Fu; Li-Man Zhou; Hao-Fu Dai; Zhi-Fang Yu; You-Xing Zhao, Tetracyclic indole alkaloids with antinematode activity from Uncaria rhynchophylla. Natural Product Research, 2017, 31: 1403-1408.
