孔凡栋老师简况

2021年03月23日 08:53

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简介

孔凡栋,男,山东菏泽人,中国海洋大学药物化学专业医学博士,副教授。担任中国菌物学会菌物化学专业委员会委员。主要从事真菌活性代谢产物研究。通过对10余株海洋真菌代谢产物进行系统研究,获得代谢产物300余个,其中新化合物100余个,包括全新骨架的化合物7个。部分化合物显示有很强的抑菌、细胞毒、细菌群体感应系统抑制、抗病毒和磷酸蛋白络氨酸激酶抑制活性。目前共参与发表SCI论文60余篇,其中第一作者SCI论文20余篇,包括6篇天然产物顶级期刊(5Journal of natural products1Organic letters)。担任Current medicinal chemistryFitoterapia Natural product research等本专业SCI期刊的审稿人。主持和完成国家自然科学基金和省部级基金等共6项,申请和授权发明专利4项。 

 


研究领域:

研究领域为天然药物化学,主要从事微生物和民族药物中先导化合物的筛选和发现研究。


近五年作为负责人主持科研项目情况:

1. 国家自然科学基金青年项目(2017-2019):三株海洋动物内生真菌中革兰氏阴性菌群体感应抑制剂研究(24万,主持

2. 海南省自然科学基金面上项目(2017-2018):两株文蛤内生真菌中革兰氏阴性菌群体感应抑制剂研究(8万,主持

3. 海南省自然科学基金青年项目(2020-2022):海口湾方格星虫来源真菌中具有杀根结线虫作用的次生代谢产物研究(5万,主持

4. 中国热带农业科学院青年科技骨干人才项目(2020-2023)(40万,主持

5. 中国热带农业科学院国家自然科学基金培育项目(2020)(10万,主持

6. 农业部中央公益性基本科研业务费(2016-2020):天然降血糖活性分子研究(160万,主持



近五年公开发表论文情况:

  1. Guo-Jun Pan; Yan-Ling Li; XinYu Che; Dan Tian; Wen-Jie Han; Zi-Min Wang;Yan-Fen Zhao; Shuang Ren; Yi-Ru Xu; Gang-Ping Hao; Meng-Fei Guo; Na Xiao*; Fan-dong Kong*; New Thio-Compounds and Monoterpenes with anti-Inflammatory Activitiesfrom the Fungus Aspergillus sp. CYH26, Frontiers in Microbiology, 2021, 12:668938. (IF = 4.235, 中科院二区)

  2. Fan-Dong Kong;Tian-Feng Yi; Qing-Yun Ma; Qing-Yi Xie; Li-Man Zhou; Jing-Ping Chen; Hao-Fu Dai; You-Gen Wu; You-Xing Zhao. Biphenyl metabolites from the patchouli endophytic fungus Alternaria sp. PfuH1. Fitoterapia, 2020, doi: 10.1016/j.fitote.2020.104708. (IF = 2.527, 中科院三区)

  3. Jiao-Chen Guo; Fan-Dong Kong (co-first); Qing-Yun Ma; Qing-Yi Xie; Ren-Shuai Zhang; Hao-Fu Dai; You-Gen Wu; You-Xing Zhao. Meroterpenoids With Protein Tyrosine Phosphatase 1B Inhibitory Activities From the Fruiting Bodies of Ganoderma ahmadii, Frontiers in chemistry, 2020, doi: 10.3389/fchem.2020.00279. (ACS, IF = 3.693, 中科院二区)

  4. Fan-Dong Kong; Peng Fan; Li-Man Zhou; Qing-Yun Ma; Qing-Yi Xie; Hai-Zhou Zheng; Zhi-Hui Zheng; Ren-Shuai Zhang; Jing-Zhe Yuan; Hao-Fu Dai; Du-Qiang Luo; You-Xing Zhao. Penerpenes A–D, Four Indole Terpenoids with Potent Protein Tyrosine Phosphatase Inhibitory Activity from the Marine-Derived Fungus Penicillium sp. KFD28. Organic letters, 2019, 21: 4864-4867. (ACS, IF = 6.555, 中科院一区,top期刊)

  5. Fan-Dong Kong; Shengliang Zhang; Shuang-Qing Zhou; Qing-Yun Ma; Qing-Yi Xie; Jin-Ping Chen; Jing-Zhe Yuan; Hao-Fu Dai; Xiaolong Huang; You-Xing Zhao. Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus Aspergillus sp. HNMF114. Journal of natural products, 2019, 82, 3456-3463 (ACS, IF = 4.257, 中科院二区).

  6. Li-Man Zhou; Fan-Dong Kong (co-first); Peng Fan; Qing-Yun Ma; Qing-Yi Xie; Hai-Zhou Zheng; Zhi-Hui Zheng; Jing-Zhe Yuan; Hao-Fu Dai; Du-Qiang Luo; You-Xing Zhao. Indole-Diterpenoids with Protein Tyrosine Phosphatase Inhibitory Activities from the Marine-Derived Fungus Penicillium sp. KFD28, Journal of natural products, 2019, 82: 2638-2644. (ACS, IF = 4.257, 中科院二区)

  7. Li-Man Zhou; Fan-Dong Kong (co-first); Qing-Yi Xie; Qing-Yun Ma; Zhong Hu; Du-Qiang Luo; You-Xing Zhao. Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18. Marine drugs, 2019, 17: 219. (IF = 3.772, 中科院二区)

  8. Fei Zhang; Fan-Dong Kong (co-first); Qing-Yun Ma; Qing-Yi Xie; Li-Man Zhou; You-Xing Zhao; Lei Guo. Polyketides with quorum sensing inhibitory activity from the marine-derived fungus Aspergillus sp. ZF-79. Journal of Asian Natural Products Research, 2019, doi: 10.1080/10286020.2019.1670647. (IF = 1.17,中科院四区)

  9. Fan-Dong Kong; Xiao-Long Huang; Qing-Yun Ma; Qing-Yi Xie; Pei Wang; Peng-Wei Chen; Li-Man Zhou; Jing-Zhe Yuan; Hao-Fu Dai; Du-Qiang Luo; You-Xing Zhao, Helvolic acid derivatives with antibacterial activities against Streptococcus agalactiae from the marine-derived fungus Aspergillus fumigatus HNMF0047. Journal of natural products, 2018, 81: 1869-1876. (ACS, IF = 4.257, 中科院二区)

  10. Guo-Liang Zhu; Fan-Dong Kong (co-first); Yi Wang; Peng Fu; Wei-Ming Zhu. Cladodionen, a cytotoxic hybrid polyketide from the marine-derived Cladosporium sp. OUCMDZ-1635. Marine drugs, 2018, 16: 71-78. (IF = 3.772, 中科院二区)

  11. Chang-Liang An; Fan-Dong Kong (co-first); Qing-Yun Ma; Qing-Yi Xie; Jing-Zhe Yuan; Li-Man Zhou; Hao-Fu Dai; Zhi-Fang Yu; You-Xing Zhao, Chemical Constituents of the Marine-Derived Fungus Aspergillus sp. SCS-KFD66. Marine drugs, 2018, 16: 468-478. (IF = 3.772, 中科院二区)

  12. Fan-Dong Kong; Qing-Yun Ma; Sheng-Zhuo Huang; Pei Wang; Jun-Feng Wang; Li-Man Zhou; Jing-Zhe Yuan; Hao-Fu Dai; You-Xing Zhao, Chrodrimanins K–N and related meroterpenoids from the fungus Penicillium sp. SCS-KFD09 isolated from a marine worm, Sipunculus nudus, Journal of Natural Products, 2017, 80: 1039-1047. (ACS, IF = 3.885, 中科院二区)

  13. Fan-Dong Kong; Li-Man Zhou; Qing-Yun Ma; Sheng-Zhuo Huang; Pei Wang; Hao-Fu Dai; You-Xing Zhao, Metabolites with Gram-negative bacteria quorum sensing inhibitory activity from the marine animal endogenic fungus Penicillium sp. SCS-KFD08, Archives of Pharmacal Research, 2017, 40: 25-31. (IF = 2.33, 中科院三区)

  14. Fan-Dong Kong; Qing-Yun Ma; Sheng-Zhuo Huang; Shuang Yang; Lin-Ran Fu; Li-Man Zhou; Hao-Fu Dai; Zhi-Fang Yu; You-Xing Zhao, Tetracyclic indole alkaloids with antinematode activity from Uncaria rhynchophylla. Natural Product Research, 2017, 31: 1403-1408. (IF = 1.928,中科院四区)

  15. Fan-Dong Kong; Ren-Shuai Zhang; Qing-Yun Ma; Qing-Yi Xie; Pei Wang; Peng-Wei Chen; Li-Man Zhou; Hao-Fu Dai; Du-Qiang Luo; You-Xing Zhao, Chrodrimanins O-S from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculusnudus. Fitoterapia, 2017, 122 : 1-6. (IF = 2.642, 中科院三区)

  16. Liang-Liang Chen; Fan-Dong Kong (co-first); Pei Wang; Jing-Zhe Yuan; Zhi-Kai Guo; Hao Wang; Hao-Fu Dai; Wen-Li Mei, Two new tremulane sesquiterpenes from a mangrove endophytic fungus, Coriolopsis sp. J5. Chinese Chemical Letters, 2017, 28: 222-225. (IF = 2.631,中科院三区)

  17. Hang Shao; Fan-Dong Kong (co-first); Hao Wang; Wen-Li Mei; Hao-Fu Dai, Qinanmer, a new compound from Chinese agarwood ‘Qi-Nan’ originating from Aquilaria sinensis, Journal of Asian Natural Products Research, 2017, 19: 935-940. (IF = 1.091,中科院四区)

  18. Fan-Dong Kong; Li-Man Zhou; Qing-Yun Ma; Sheng-Zhuo Huang; Pei Wang; Hao-Fu Dai; You-Xing Zhao, Penicillars A-E from the marine animal endogenic fungus Penicillium sp. SCS-KFD08. Phytochemistry Letters, 2016, 17: 59-63. (IF = 1.418,中科院四区)

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